São Gabriel da Cachoeira, Brazilian municipality with the greatest indigenous predominance in the country, was affected by a sharp increase in COVID-19 cases in the state of Amazonas between January and February 2021. MSF treated moderate cases in a primary health care unit (UBS Miguel Quirino) and implemented rapid antigen testing. Health promotion teams also carried out activities in the Baniwa, Nheengatu, Tukano and Portuguese languages on prevention and social distancing measures, as well as distributed hygiene kits.